Influence of temperature gradual variation over skin microcirculation responses to thermal stimulation
ResumoThe study of the mechanisms involved in the local temperature control is a model used to understand vascular
pathology, especially when endothelium dysfunction is the issue. This study aims to systematize and to compare the
response to local changes in temperature, by studying the influence of the heating rate over the response. Several
local heating protocols working at 42 or 44ºC were performed in the forearm of healthy, female, non smokers
volunteers (n=10). Skin microcirculation was evaluated by Laser Doppler Flowmetry during 30 minutes. A new
parameter “nadir/peak” (N/P) was calculated to distinguish the shape of the hyperemic response - biphasic when N/P
<1 and monophasic when N/P >1. At 42ºC the shape is biphasic, independently of the rate of heating. At 44ºC the
shape was always monophasic. This suggested that local response to heating is dependent from the rate of heating
and probably from the activation of nociceptor fibers.
Sep 22, 2010
PINTO, Pedro Contreiras; VARGAS, Helena; RODRIGUES, Luis Monteiro. Influence of temperature gradual variation over skin microcirculation responses to thermal stimulation. Revista Lusófona de Ciências e Tecnologias da Saúde, [S.l.], n. 2, sep. 2010. ISSN 1646-3854. Disponível em: <http://revistas.ulusofona.pt/index.php/revistasaude/article/view/2772>. Acesso em: 22 june 2018.
Ciências Biomédicas / Biomedical Sciences
Microcirculation, thermal hyperemia, Laser Doppler