Assessment of skin barrier function using mathematical modeling of TEWL-desorption curves: age related differences
ResumoThe study aimed to investigate changes in the cutaneous barrier function caused by ageing using the POST (plastic
occlusion stress test) methodology followed by mathematical modeling of the TEWL data obtained after removal of the
32 healthy volunteers participated in the study. They were separated into two groups: one of volunteers under and the other
of subjects over 30 years old. An occlusive patch was applied to the ventral forearm of each volunteer for 2 hours. After
removal of the patch, the TEWL was measured for 30 minutes. A bi-compartmental mathematical model was fitted to the
data and t1/2evap – evaporation half-life- and DWM – dynamic water mass- were calculated.
Discrete differences were found between the kinetic parameters obtained for the two groups, which seems to indicate that
the water balance and skin barrier were not severely altered in the age ranges included in the study. Nevertheless, the
desorption curves of the under 30 volunteers presented a sharp decay, whereas in senile skin the decay occurred at a much
It can be concluded that the dynamic methodology was able to establish a mild differences in the water dynamics of aged
skin, which can potentially be applied to the efficacy and safety testing of skin products.
Sep 22, 2010
NUNES, Felipe et al. Assessment of skin barrier function using mathematical modeling of TEWL-desorption curves: age related differences. Revista Lusófona de Ciências e Tecnologias da Saúde, [S.l.], n. 2, sep. 2010. ISSN 1646-3854. Disponível em: <http://revistas.ulusofona.pt/index.php/revistasaude/article/view/2776>. Acesso em: 27 apr. 2017.
Ciências Biofarmacêuticas / Biopharmaceutical Sciences
barrier function; POST; TEWL; ageing.