Using Skin Surface Biopsy as an In Vivo Model to Study Skin Lesion
Palavras-chave: Skin Surface Biopsy, Cutaneous lesion, Micromodel, Non-invasive access
ResumoThe Skin Surface Biopsy (SSB) is an easy application technique with an interesting potential to be used as a micromodel to study in vivo human skin lesion and recovery mechanisms. It is known that the SSB application modifies skin's integrity and compromises its barrier function. As a consequence, it allows the quantitative monitoring of the implied pathophysiological mechanisms. The main objective of this study is to evaluate the SSB impact in the functional properties of the skin and the application of this strategy to study the cutaneous wound. The considered relevant variables were obtained trough non invasive techniques, being Transepidermal Water Loss (TEWL), Colorimetry, Local microcirculation and ecogenecity of the skin. Results suggest that SSB significantly changed the functional properties of the skin, suggesting that this model may be interesting to monitor in vivo the evaluation of the mechanisms involved in cutaneous lesion and healing.
Ciências Biomédicas / Biomedical Sciences