Using Skin Surface Biopsy as an In Vivo Model to Study Skin Lesion

  • Maria Madalena Pereira Universidade Lusófona de Humanidades e Tecnologias
  • Joana Saraiva Universidade Lusófona
  • Luis Monteiro Rodrigues Universidade Lusófona


The Skin Surface Biopsy (SSB) is an easy application technique with an interesting potential to be used as a
micromodel to study in vivo human skin lesion and recovery mechanisms. It is known that the SSB application
modifies skin's integrity and compromises its barrier function. As a consequence, it allows the quantitative
monitoring of the implied pathophysiological mechanisms. The main objective of this study is to evaluate the SSB
impact in the functional properties of the skin and the application of this strategy to study the cutaneous wound.
The considered relevant variables were obtained trough non invasive techniques, being Transepidermal Water Loss
(TEWL), Colorimetry, Local microcirculation and ecogenecity of the skin.
Results suggest that SSB significantly changed the functional properties of the skin, suggesting that this model may
be interesting to monitor in vivo the evaluation of the mechanisms involved in cutaneous lesion and healing.


Sep 22, 2010
Como citar
PEREIRA, Maria Madalena; SARAIVA, Joana; RODRIGUES, Luis Monteiro. Using Skin Surface Biopsy as an In Vivo Model to Study Skin Lesion. Revista Lusófona de Ciências e Tecnologias da Saúde, [S.l.], n. 2, sep. 2010. ISSN 1646-3854. Disponível em: <>. Acesso em: 20 sep. 2019.
Ciências Biomédicas / Biomedical Sciences


Skin Surface Biopsy, Cutaneous lesion, Micromodel, Non-invasive access